Gut microbiota influence the ability to lose weight in humans, according to new research. The findings were published this week in mSystems, an open-access journal of the American Society for Microbiology.
Published: September 14, 2021
Source: American Society for Microbiology
To conduct their research, Dr. Diener and colleagues focused on a large cohort of individuals who were involved in a lifestyle intervention study. Instead of a specific diet or exercise program, this intervention involved a commercial behavioural coaching program paired with advice from a dietician and nurse coach. The researchers focused on 48 individuals who lost more than 1% of their body weight per month over a 6 to 12 month period and 57 individuals who did not lose any weight and had a stable body mass index (BMI) over the same period. The researchers relied on metagenomics, the study of genetic material recovered from blood and stool samples. The individuals analysed blood metabolites, blood proteins, clinical labs, dietary questionnaires and gut bacteria in the two groups.
After controlling for age, sex and baseline BMI, the researchers identified 31 baseline stool metagenomic functional features that were associated with weight loss responses. These included complex polysaccharide and protein degradation genes, stress-response genes, respiration-related genes, cell wall synthesis genes and gut bacterial replication rates. A major finding was that the ability of the gut microbiome to break down starches was increased in people who did not lose weight. Another key finding was that genes that help bacteria grow faster, multiply, replicate and assemble cell walls were increased in people who lost more weight.
"Before this study, we knew the composition of bacteria in the gut were different in obese people than in people who were non-obese, but now we have seen that there are a different set of genes that are encoded in the bacteria in our gut that also responds to weight loss interventions," said Dr. Diener. "The gut microbiome is a major player in modulating whether a weight loss intervention will have success or not. The factors that dictate obesity versus nonobesity are not the same factors that dictate whether you will lose weight on a lifestyle intervention."
Research has already shown that if you change your diet, you can alter the composition of bacteria in your gut.
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Materials provided by American Society for Microbiology. Content may be edited for style and length.
- Christian Diener, Shizhen Qin, Yong Zhou, Sushmita Patwardhan, Li Tang, Jennifer C. Lovejoy, Andrew T. Magis, Nathan D. Price, Leroy Hood, Sean M. Gibbons, Henrik Munch Roager. Baseline Gut Metagenomic Functional Gene Signature Associated with Variable Weight Loss Responses following a Healthy Lifestyle Intervention in Humans. mSystems, 2021; DOI: 10.1128/mSystems.00964-21